کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10871995 | 1074095 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human initiation factor eIF3 subunit b interacts with HCV IRES RNA through its N-terminal RNA recognition motif
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
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![عکس صفحه اول مقاله: Human initiation factor eIF3 subunit b interacts with HCV IRES RNA through its N-terminal RNA recognition motif Human initiation factor eIF3 subunit b interacts with HCV IRES RNA through its N-terminal RNA recognition motif](/preview/png/10871995.png)
چکیده انگلیسی
Many viral mRNAs contain a 5â²-UTR RNA element called internal ribosome-entry site (IRES), which bypasses the requirement of some canonical initiation factors allowing cap-independent translation. The IRES of hepatitis-C virus drives translation by directly recruiting 40S ribosomal subunits and binds to eIF3 which plays a critical role in both cap-dependent and cap-independent translation. However, the molecular basis for eIF3 activity in either case remains enigmatic. Here we report that subunit b of the eIF3 complex directly binds to HCV IRES domain III via its N-terminal-RRM. Because eIF3b was previously shown to be involved in eIF3j binding, biological implications are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 1, 5 January 2009, Pages 70-74
Journal: FEBS Letters - Volume 583, Issue 1, 5 January 2009, Pages 70-74
نویسندگان
Julien Pérard, Rodolfo Rasia, Jan Medenbach, Isabel Ayala, Jérôme Boisbouvier, Emmanuel Drouet, Florence Baudin,