کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872044 | 1074097 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel splice variant of mouse insulin2 mRNA: Implications for insulin expression
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel splice variant of mouse insulin2 mRNA: Implications for insulin expression Novel splice variant of mouse insulin2 mRNA: Implications for insulin expression](/preview/png/10872044.png)
چکیده انگلیسی
Insulin is a secreted peptide that controls glucose homeostasis in mammals, and insulin biosynthesis is regulated by glucose at many levels. Rodent insulin is encoded by two non-allelic genes. We have identified a novel splice variant of the insulin2 gene in mice that constitutes about 75% of total insulin2 mRNA. The alternate splicing does not alter the ORF but reduces the 5â²UTR by 12 bases. A reporter gene containing the novel short 5â²UTR, is more efficiently expressed in cells, suggesting that alternative splicing of insulin mRNA in mice could result in an additional level of regulation in insulin biosynthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 584, Issue 6, 19 March 2010, Pages 1169-1173
Journal: FEBS Letters - Volume 584, Issue 6, 19 March 2010, Pages 1169-1173
نویسندگان
Amaresh C. Panda, Shardul D. Kulkarni, Bhavana Muralidharan, Baskar Bakthavachalu, Vasudevan Seshadri,