کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872148 1074105 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serpins show structural basis for oligomer toxicity and amyloid ubiquity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Serpins show structural basis for oligomer toxicity and amyloid ubiquity
چکیده انگلیسی
Many disorders, including Alzheimer's, the prion encephalopathies and other neurodegenerative diseases, result from aberrant protein aggregation. Surprisingly, cellular toxicity is often due not to the highly-ordered aggregates but to the oligomers that precede their formation. Using serpins as a paradigm, we show how the active and infective interface of oligomers is inherently toxic and can promiscuously bind to unrelated peptides, including neurotransmitters. Extension of the oligomer and its eventual sequestration as amyloid can thus be seen as a protective response to block the toxic interface. We illustrate how the preferential self-association that gives this protection has been selectively favoured.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 17, 23 July 2008, Pages 2537-2541
نویسندگان
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