کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872190 1074110 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway
چکیده انگلیسی
The molecular mechanism of the anti-adipogenic effect of evodiamine (which has several capsaicin-like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3-L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKCα, and ERK, all of which were reduced by an EGFR inhibitor. Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine. An unidentified mechanism whereby evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway was revealed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 22, 19 November 2009, Pages 3655-3659
نویسندگان
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