کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872198 1074110 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network
چکیده انگلیسی
The von Hippel-Lindau (VHL) tumor suppressor gene is a protein interaction hub, controlling numerous genes implicated in tumor progression. Here we focus on structural aspects of protein interactions for a list of 35 experimentally verified protein VHL (pVHL) interactors. Using structural information and computational analysis we have located three distinct interaction interfaces (A, B, and C). Interface B is the most versatile, recognizing a refined linear motif present in 17 otherwise non-related proteins. It has been possible to distinguish compatible and exclusive interactions by relating pVHL function to interaction interfaces and subcellular localization. A novel hypothesis is presented regarding the possible function of the N-terminus as an inhibitor of pVHL function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 22, 19 November 2009, Pages 3704-3710
نویسندگان
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