کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10872392 1074136 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Response of zonal chondrocytes to extracellular matrix-hydrogels
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Response of zonal chondrocytes to extracellular matrix-hydrogels
چکیده انگلیسی
We investigated the biological response of chondrocytes isolated from different zones of articular cartilage and their cellular behaviors in poly (ethylene glycol)-based (PEG) hydrogels containing exogenous type I collagen, hyaluronic acid (HA), or chondroitin sulfate (CS). The cellular morphology was strongly dependent on the extracellular matrix component of hydrogels. Additionally, the exogenous extracellular microenvironment affected matrix production and cartilage specific gene expression of chondrocytes from different zones. CS-based hydrogels showed the strongest response in terms of gene expression and matrix accumulation for both superficial and deep zone chondrocytes, but HA and type I collagen-based hydrogels demonstrated zonal-dependent cellular responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 22, 4 September 2007, Pages 4172-4178
نویسندگان
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