کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872405 | 1074136 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system](/preview/png/10872405.png)
چکیده انگلیسی
In Saccharomyces cerevisiae, one of two cytosolic lysine-tRNAs is partially imported into mitochondria. We demonstrate that three components of the ubiquitin/26S proteasome system (UPS), Rpn13p, Rpn8p and Doa1p interact with the imported tRNA and with the essential factor of its mitochondrial targeting, pre-Msk1p. Genetic and biochemical assays demonstrate that UPS plays a dual regulatory role, since the overall inhibition of cellular proteasome activity reduces tRNA import, while specific depletion of Rpn13p or Doa1p increases it. This result suggests a functional link between UPS and tRNA mitochondrial import in yeast and indicates on the existence of negative and positive import regulators.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 581, Issue 22, 4 September 2007, Pages 4248-4254
Journal: FEBS Letters - Volume 581, Issue 22, 4 September 2007, Pages 4248-4254
نویسندگان
Irina Brandina, Alexandre Smirnov, Olga Kolesnikova, Nina Entelis, Igor A. Krasheninnikov, Robert P. Martin, Ivan Tarassov,