کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872537 | 1074167 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation](/preview/png/10872537.png)
چکیده انگلیسی
The CSF-1 receptor is a protein-tyrosine kinase that regulates the renewal, differentiation and activation of monocytes and macrophages. We have recently shown that the CSF-1 receptor undergoes regulated intramembrane proteolysis, or RIPping. Here, we report that RIPping can be observed in response to pathogen-associated molecules, which act through Toll-like receptors (TLRs). TLR-induced CSF-1 receptor RIPping is largely independent of protein kinase C, while maximal RIPping depends on Erk activation. Our studies show that CSF-1 receptor RIPping can be activated by various intracellular signal transduction pathways and that RIPping is likely to play an important role during macrophage activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 582, Issue 6, 19 March 2008, Pages 911-915
Journal: FEBS Letters - Volume 582, Issue 6, 19 March 2008, Pages 911-915
نویسندگان
Gary Glenn, Peter van der Geer,