کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872683 | 1074212 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of GSK3β by indirubins restores HIF-1α accumulation under prolonged periods of hypoxia/anoxia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibition of GSK3β by indirubins restores HIF-1α accumulation under prolonged periods of hypoxia/anoxia Inhibition of GSK3β by indirubins restores HIF-1α accumulation under prolonged periods of hypoxia/anoxia](/preview/png/10872683.png)
چکیده انگلیسی
Hypoxia inducible factor 1 is regulated by the appearance of the HIF-1α subunit. HIF-1α is subjected to proteasomal destruction or enhanced protein translation, which requires the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. We investigated how PI3K/Akt and glycogen synthase kinase 3β (GSK3β) affect HIF-1α in human RKO cells under prolonged periods of severe hypoxia/anoxia. 16- to 32-h lasting incubations attenuated Akt activity and decreased HIF-1α protein. This was reproduced by blocking PI3K with LY294002. GSK3β inhibition by indirubins circumvented the effect of hypoxia/anoxia or LY294002 on HIF-1α. Ruling stability regulation of HIF-1α protein and/or enhanced transcription of HIF-1α mRNA via GSK3β inhibition out is suggestive for translational modulation of HIF-1α under the influence of GSK3β.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 2, 17 January 2005, Pages 529-533
Journal: FEBS Letters - Volume 579, Issue 2, 17 January 2005, Pages 529-533
نویسندگان
Steffen E. Schnitzer, Tobias Schmid, Jie Zhou, Gerhard Eisenbrand, Bernhard Brüne,