کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872842 | 1074252 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells](/preview/png/10872842.png)
چکیده انگلیسی
The effect of different classes of dietary polyphenols on intestinal glucose uptake was investigated using polarised Caco-2 intestinal cells. Glucose uptake into cells under sodium-dependent conditions was inhibited by flavonoid glycosides and non-glycosylated polyphenols whereas aglycones and phenolic acids were without effect. Under sodium-free conditions, aglycones and non-glycosylated polyphenols inhibited glucose uptake whereas glycosides and phenolic acids were ineffective. These data suggest that aglycones inhibit facilitated glucose uptake whereas glycosides inhibit the active transport of glucose. The non-glycosylated dietary polyphenols appear to exert their effects via steric hindrance, and (â)-epigallochatechingallate, (â)-epichatechingallate and (â)-epigallochatechin are effective against both transporters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 7, 14 March 2005, Pages 1653-1657
Journal: FEBS Letters - Volume 579, Issue 7, 14 March 2005, Pages 1653-1657
نویسندگان
Kelly Johnston, Paul Sharp, Michael Clifford, Linda Morgan,