کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10872961 | 1074253 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10 Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10](/preview/png/10872961.png)
چکیده انگلیسی
Tau exon 10 (E10) splicing is a crucial event in its developmental change of tau isoform and tauopathy. To investigate the splicing mechanism, we isolated and compared mouse tau genomic sequence with human sequence. We identified a new element in mouse intron 10 (I10) to suppress E10 splicing, which was located just after the stem-loop region previously proposed in human sequence and found to potentially form another stem-loop. Human I10 with a mutation (+29G to A) causing a decreased E10 splicing was also predicted to form similar double stem-loop, suggesting that this element is universally involved in regulation of E10 splicing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 1, 3 January 2005, Pages 241-244
Journal: FEBS Letters - Volume 579, Issue 1, 3 January 2005, Pages 241-244
نویسندگان
Takenari Yamashita, Takami Tomiyama, Qiang Li, Hideharu Numata, Hiroshi Mori,