Scyphozoan jellyfish venom metalloproteinases and their role in the cytotoxicity

► We discovered multiple metalloproteinases in the Scyphozoan jellyfish venoms. ► All the venoms tested show gelatinolytic, caseinolytic, and fibrinolytic activities. ► The venom MMP activities have a positive correlation with their cytotoxicities. ► The MMPs appear to play an important role in the induction of venom toxicities.