کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10881813 1077923 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Protective effect of ginkgo biloba against gossypol-induced apoptosis in human lymphocytes
چکیده انگلیسی
Ginkgo biloba (EGb 761) is a well-defined plant extract that directly scavenges hydroxyl radicals. It is a potent antioxidant that inhibits apoptosis in cultured cells and is effective in treating mild-to-moderate dementia in Alzheimer patients. Apoptosis is an active process of cell destruction and it plays an important role in pathological processes. The aim of this study is to investigate the anti-apoptotic effect of EGb 761 in gossypol-treated human lymphocytes. Pretreatment of lymphocytes with 10 μg/ml EGb 761 for 30 min or 1 h decreased the percentage of apoptosis to 17.5% and 20%, respectively. EGb 761 treatment (25-150 μg/ml) decreased the level of apoptosis to a plateau between 8 and 10% of the control values. We conclude that EGb 761 reduces gossypol-induced apoptosis in human lymphocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 29, Issue 8, August 2005, Pages 717-720
نویسندگان
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