کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10881817 | 1077924 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabolic alterations in K562 cells exposed to taxol and tyrphostin AG957: 1H NMR and biochemical studies
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
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چکیده انگلیسی
K562 cells exposed for 3Â h to taxol or taxol plus tyrphostin AG957 exhibited a significant variation in the concentration of the water-soluble metabolites glutathione, myo-inositol and phosphorylcholine, as evaluated by 1H NMR up to 72Â h incubation in drug-free medium. Cells treated with both drugs showed an increase of glutathione and glutathione reductase at 24Â h and a sharp decrease of myo-inositol between 8 and 24Â h. Phosphorylcholine increased at 8Â h both in taxol and taxol plus AG957-treated cells, which was then abruptly inverted to a significantly lower concentration at 24Â h, subsequently increasing again to values higher than those found in taxol-treated and control cells. All the above reported effects were lacking in cells exposed to AG957 alone. These modifications, despite the enhancement of the overall apoptotic cascade in taxol plus AG957-treated cells, can be related to the activation of cellular detoxification mechanisms, to the correct osmolarity maintenance, and to alterations of phospholipid metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 29, Issue 11, November 2005, Pages 890-897
Journal: Cell Biology International - Volume 29, Issue 11, November 2005, Pages 890-897
نویسندگان
Arno Knijn, Fabrizia Brisdelli, Amalia Ferretti, Egidio Iorio, Donatella Marcheggiani, Argante Bozzi,