High expression of Mfn1 promotes early development of bovine SCNT embryos: Improvement of mitochondrial membrane potential and oxidative metabolism

► Mfn1 level in bovine cloned embryo can be altered by transgenic or RNAi technology. ► Upregulation of Mfn1 will increase the development rate of bovine cloned embryo. ► Overexpression of Mfn1 in bovine cloned embryo will restrain the fragmentation. ► Overexpression of Mfn1will enhance ATP generation and increase Δψm. ► Upregulation of Mfn1 will decrease H2O2 concentration in bovine cloned embryos.