کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10883132 | 1078355 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration
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کلمات کلیدی
IMACPTPVDACToMTIMROS - ROSPermeability transition pore - افت فشار نفوذ پذیریtranslocase of the outer membrane - انتقال غشای خارجیtranslocase of the inner membrane - انتقال غشای داخلیDegenerative diseases - بیماری های تخریبیCancer - سرطانMAC - مکBcl-2 homology - همولوگ Bcl-2Reactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration](/preview/png/10883132.png)
چکیده انگلیسی
Mitochondria communicate with the rest of the cell through channels located in their inner and outer membranes. Most of the time, the message is encoded by the flow of anions and cations e.g., through VDAC and PTP, respectively. However, proteins are also both imported and exported across the mitochondrial membranes e.g., through TOM and MAC, respectively. Transport through mitochondrial channels is exquisitely regulated and controls a myriad of processes; from energy production to cell death. Here, we examine the role of some of the mitochondrial channels involved in neurodegeneration, ischemia-reperfusion injury and cancer in the context of their potential as therapeutic targets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 12, Issue 1, January 2012, Pages 14-23
Journal: Mitochondrion - Volume 12, Issue 1, January 2012, Pages 14-23
نویسندگان
Pablo M. Peixoto, Laurent M. Dejean, Kathleen W. Kinnally,