کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10883476 1078415 2005 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nuclear and mitochondrial DNA repair: similar pathways?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Nuclear and mitochondrial DNA repair: similar pathways?
چکیده انگلیسی
Mitochondrial DNA (mtDNA) alterations are implicated in a broad range of human diseases and alterations of the mitochondrial genome are assumed to be a result of its high susceptibility to oxidative damage and its limited DNA repair compared to nuclear DNA (nDNA). Characterization of DNA repair mechanisms has generally focused on these processes in nDNA but increasing interest and research effort have contributed to our knowledge of the mechanisms underlying DNA repair in mitochondria. In this review, we make comparisons between nDNA and mtDNA repair pathways and propose a model for how these pathways interact in mitochondria.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 5, Issue 2, April 2005, Pages 89-108
نویسندگان
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