کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10884615 1079422 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inversion and crossover recombination contributions to the spacing between two functionally linked genes
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Inversion and crossover recombination contributions to the spacing between two functionally linked genes
چکیده انگلیسی
The roles of inversion and crossover recombination in determining the spacing between two functionally linked genes on an individual strand of DNA and the resulting genetic organization throughout the population is not well understood. We employ a computer simulation to look at the spacing between functionally linked genes after many generations of a population of haploid individuals, each with a single chromosome. Simulations show that inversion and crossover recombination combine to create four attractors in gene spacing. The two major attractors include one in which the linked genes are forced to be near each other and one in which the linked genes are forced to be separated by one third of the chromosome length. Multiplicative functional linkage between two linked genes also causes a decreased average spacing compared to additive and random functional linkage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 109, Issue 2, August 2012, Pages 169-178
نویسندگان
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