کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10884636 1079434 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scale-free dynamics of somatic adaptability in immune system
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات مدل‌سازی و شبیه سازی
پیش نمایش صفحه اول مقاله
Scale-free dynamics of somatic adaptability in immune system
چکیده انگلیسی
The long-time dynamics of somatic adaptability in immune system is simulated by a simple physical model defined in the shape space. The immune system described by the model exhibits a scale free behavior as is observed in living systems. The balance between the positive and negative feedbacks of the model leads to a robust immune system where the positive one corresponds to the formation of memory cells and the negative one to immunosuppression. Also the immunosenescence of the system is discussed based on the time-dependence of the epigenetic landscape of the adaptive immune cells in the shape space.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 103, Issue 3, March 2011, Pages 420-424
نویسندگان
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