کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10884643 | 1079472 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
مدلسازی و شبیه سازی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes Detecting correlation between sequence and expression divergences in a comparative analysis of human serpin genes](/preview/png/10884643.png)
چکیده انگلیسی
Physiological functions and characteristic structures of the serpin gene superfamily have been studied extensively, yet the evolution of the serpin genes remains unclear. Gene duplication in this superfamily may shed light on this issue. Two models are used to predict the preservation of duplicated genes: the classical model and the duplication-degeneration-complementation (DDC) model. In this study, we analyzed the phylogenetic relationships of 33 human serpin genes and the expression data of some members of the serpin superfamily from a DNA microarray of human leukemia U937 cells with stably inducible expression of the leukemia-related AML1-ETO gene. We then determined the utility of the DDC model by mapping serpin superfamily expression data to the phylogenetic tree. The correlation between sequence and expression divergences as measured by the Pearson correlation coefficient indicated that human serpin genes evolved under the DDC model. Our study provides a new strategy for comparative analysis of gene sequences and microarray data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosystems - Volume 82, Issue 3, December 2005, Pages 226-234
Journal: Biosystems - Volume 82, Issue 3, December 2005, Pages 226-234
نویسندگان
Zuofeng Li, Qi Liu, Mangen Song, Ying Zheng, Peng Nan, Ying Cao, Guoqiang Chen, Yixue Li, Yang Zhong,