کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10885682 1079897 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stabilization of protein-protein interaction complexes through small molecules
ترجمه فارسی عنوان
تثبیت مجتمع های پروتئین-پروتئین از طریق مولکول های کوچک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
Most of the small molecules that have been identified thus far to modulate protein-protein interactions (PPIs) are inhibitors. Another promising way to interfere with PPI-associated biological processes is to promote PPI stabilization. Even though PPI stabilizers are still scarce, stabilization of PPIs by small molecules is gaining momentum and offers new pharmacological options. Therefore, we have performed a literature survey of PPI stabilization using small molecules. From this, we propose a classification of PPI stabilizers based on their binding mode and the architecture of the complex to facilitate the structure-based design of stabilizers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 1, January 2016, Pages 48-57
نویسندگان
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