کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10885683 1079897 2016 40 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In silico assessment of adverse drug reactions and associated mechanisms
ترجمه فارسی عنوان
در ارزیابی سیلیکا واکنش های جانبی و مکانیسم های مرتبط
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
During recent years, various in silico approaches have been developed to estimate chemical and biological drug features, for example chemical fragments, protein targets, pathways, among others, that correlate with adverse drug reactions (ADRs) and explain the associated mechanisms. These features have also been used for the creation of predictive models that enable estimation of ADRs during the early stages of drug development. In this review, we discuss various in silico approaches to predict these features for a certain drug, estimate correlations with ADRs, establish causal relationships between selected features and ADR mechanisms and create corresponding predictive models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 1, January 2016, Pages 58-71
نویسندگان
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