کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10885770 1079902 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intracellular transport of nanocarriers across the intestinal epithelium
ترجمه فارسی عنوان
حمل و نقل داخل سلولی نانوذرات در سراسر اپیتلیوم روده
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
The intestinal epithelium is the main barrier restricting the oral delivery of low-permeability drugs. Over recent years, numerous nanocarriers have been designed to improve the efficiency of oral drug delivery. However, the intracellular processes determining the transport of nanocarriers across the intestinal epithelium remain elusive, and only limited enhancement of the oral bioavailability of drugs has been achieved. Here, we review the processes involved in nanocarrier trafficking across the intestinal epithelium, including apical endocytosis, intracellular transport, and basolateral exocytosis. Understanding the complex intracellular processes of nanocarrier trafficking is particularly essential for the rational design of oral drug delivery systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 5, May 2016, Pages 856-863
نویسندگان
, , , , ,