کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10885774 | 1079903 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunotoxin therapy for hematologic malignancies: where are we heading?
ترجمه فارسی عنوان
درمان ایمنوتوکسین برای بدخیمی های هماتولوژیک: ما کجا هستیم؟
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
چکیده انگلیسی
The identification of numerous unique targets in recent years has led to the development of various immunotoxins (ITs) for treating hematological malignancies. Some of these ITs have advanced to clinical trials and have resulted in a high response rate against leukemia. Newer targets with improve specificity are also being identified for targeting several leukemias. Currently, several modified versions of ITs with increased efficacy are being constructed and evaluated for cytotoxicity in vitro as well as in vivo. Here, we summarize recent advances in preclinical and clinical studies of recombinant ITs targeting diverse surface receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today - Volume 21, Issue 2, February 2016, Pages 325-332
Journal: Drug Discovery Today - Volume 21, Issue 2, February 2016, Pages 325-332
نویسندگان
Jayaprakasam Madhumathi, Sithambaram Devilakshmi, Surapally Sridevi, Rama S. Verma,