Structures of G protein-coupled receptors reveal new opportunities for drug discovery

- X-ray structures are now available for more than 60 ligands and 20 GPCRs.
- Structures reveal details of ligand biding that could not be predicted.
- Structure-based drug design for GPCRs has been transformed by the new results.
- Lipophilic sites and water molecules have key roles in ligand-binding properties.