Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases

- Inactivity is an important and independent risk factor for many diseases.
- Exercise ameliorates the symptoms of metabolic and other pathologies.
- 'Exercise mimetics' are pharmacological agents that elicit exercise-like effects.
- AMPK and SIRT1 activation mimics adaptation to endurance training.
- PGC-1α is the putative mediator of AMPK and SIRT1 activation in muscle.