کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899316 | 1084363 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ovarian cancer stem-like cells differentiate into endothelial cells and participate in tumor angiogenesis through autocrine CCL5 signaling
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کلمات کلیدی
STAT3NF-κBCcl5EPCsCSCsHUVECSECs - EC هاAngiogenesis - آنژیوژنزEndothelial cell differentiation - تمایز سلول اندوتلیالOvarian cancer - سرطان تخمدانHuman umbilical vein endothelial cells - سلول های اندوتلیالی ورید ناف انسانcancer stem-like cells - سلول های بنیادی سرطانیEndothelial progenitor cells - سلول های پیش ساز اندوتلیالEndothelial cells - سلولهای اندوتلیالcancer stem cell - سلولهای بنیادی سرطانیCancer stem cells - سلولهای بنیادی سرطانیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)nuclear factor kappa B - فاکتور هسته ای کاپا Bsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cancer stem cells (CSCs) are well known for their self-regeneration and tumorigenesis potential. In addition, the multi-differentiation potential of CSCs has become a popular issue and continues to attract increased research attention. Recent studies demonstrated that CSCs are able to differentiate into functional endothelial cells and participate in tumor angiogenesis. In this study, we found that ovarian cancer stem-like cells (CSLCs) activate the NF-κB and STAT3 signal pathways through autocrine CCL5 signaling and mediate their own differentiation into endothelial cells (ECs). Our data demonstrate that CSLCs differentiate into ECs morphologically and functionally. Anti-CCL5 antibodies and CCL5-shRNA lead to markedly inhibit EC differentiation and the tube formation of CSLCs, both in vitro and in vivo. Recombinant human-CCL5 significantly promotes ovarian CSLCs that differentiate into ECs and form microtube network. The CCL5-mediated EC differentiation of CSLCs depends on binding to receptors, such as CCR1, CCR3, and CCR5. The results demonstrated that CCL5-CCR1/CCR3/CCR5 activates the NF-κB and STAT3 signal pathways, subsequently mediating the differentiation of CSLCs into ECs. Therefore, this study was conducted based on the theory that CSCs improve tumor angiogenesis and provides a novel strategy for anti-angiogenesis in ovarian cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 376, Issue 1, 28 June 2016, Pages 137-147
Journal: Cancer Letters - Volume 376, Issue 1, 28 June 2016, Pages 137-147
نویسندگان
Shu Tang, Tong Xiang, Shuo Huang, Jie Zhou, Zhongyu Wang, Rongkai Xie, Haixia Long, Bo Zhu,