کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899434 | 1084375 | 2016 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Examining the connectivity between different cellular processes in the Barrett tissue microenvironment
ترجمه فارسی عنوان
بررسی اتصال بین فرآیندهای سلولی مختلف در محیط میکروسافت بافت برکت
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
مرطوب کننده مری فسفوریلاسیون اکسیداتیو، گلیکولیز، التهاب هیپوکسیا، چاقی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and its connection with other central cellular processes within the Barrett microenvironment is unknown. The aim of this study was to examine the relationship between metabolism (ATP5B/GAPDH), hypoxia (HIF1α), inflammation (IL1β/SERPINA3), p53 and obesity status using in-vivo and ex-vivo models of Barrett oesophagus. At the protein level, ATP5B (râ=â0.71, Pâ<â0.0001) and p53 (râ=â0.455, Pâ=â0.015) were found to be strongly associated with hypoxia. In addition, levels of ATP5B (râ=â0.53, Pâ=â0.0031) and GAPDH (râ=ââ0.39, Pâ=â0.0357) were positively associated with p53 expression. Moreover, we demonstrate that ATP5B (râ=â0.8, Pâ<â0.0001) and GAPDH (râ=â0.43, Pâ=â0.022) were positively associated with IL1β expression. Interestingly, obesity was negatively associated with oxidative phosphorylation (râ=ââ0.6016, Pâ=â0.0177) but positively associated with glycolysis (râ=â0.743, Pâ=â0.0015). Comparable correlations were exhibited in the ex-vivo explant tissue between metabolism, p53, hypoxia, inflammation and angiogenesis (Pâ<â0.05). We have shown that metabolism is closely linked with many cellular processes in the Barrett tissue microenvironment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 371, Issue 2, 28 February 2016, Pages 334-346
Journal: Cancer Letters - Volume 371, Issue 2, 28 February 2016, Pages 334-346
نویسندگان
J.J. Phelan, R. Feighery, O.S. Eldin, S.Ã. Meachair, A. Cannon, R. Byrne, F. MacCarthy, D. O'Toole, J.V. Reynolds, J. O'Sullivan,