کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899497 | 1084381 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2â²-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2â²-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2â²-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics](/preview/png/10899497.png)
چکیده انگلیسی
Aberrant methylation of the transcription factor AP-2 epsilon (TFAP2E) has been attributed to 5-fluorouridine (5-FU) sensitivity. 5-Aza-2â²-deoxycytidine (DAC), an epigenetic drug that inhibits DNA methylation, is able to cause reactive expression of TFAP2E by demethylating activity. This property might be useful in enhancing the sensitivity of cancer cells to 5-FU. However, the effect of DAC is transient because of its instability. Here, we report the use of intelligent gelatinases-stimuli nanoparticles (NPs) to coencapsulate and deliver DAC and 5-FU to gastric cancer (GC) cells. The results showed that NPs encapsulating DAC, 5-FU, or both could be effectively internalized by GC cells. Furthermore, we found that the NPs enhanced the stability of DAC, resulting in improved re-expression of TFAP2E. Thus, the incorporation of DAC into NPs significantly enhanced the sensitivity of GC cells to 5-FU by inhibiting cell growth rate and inducing cell apoptosis. In conclusion, the results of this study clearly demonstrated that the gelatinases-stimuli NPs are an efficient means to simultaneously deliver epigenetic and chemotherapeutic drugs that may effectively inhibit cancer cell proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 363, Issue 1, 10 July 2015, Pages 7-16
Journal: Cancer Letters - Volume 363, Issue 1, 10 July 2015, Pages 7-16
نویسندگان
Feng-lei Wu, Ru-Tian Li, Mi Yang, Guo-Feng Yue, Hui-yu Wang, Qin Liu, Fang-bo Cui, Pu-yuan Wu, Hui Ding, Li-Xia Yu, Xiao-Ping Qian, Bao-Rui Liu,