Keywords: Lynch syndrome; Endometrial cancer; Ovarian cancer; Endometrial hyperplasia; Hypermethylation; Mismatch repair;
مقالات ISI (ترجمه نشده)
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Keywords: Ovarian cancer; Suppresser tumor gene; Hypermethylation; Hidden Markov models;
Keywords: Metallothioneins; Cancer; Diagnosis; Therapy; Hypermethylation;
Keywords: Purinergic receptor; Salivary glands; DNA methylation; Hypomethylation; Hypermethylation; 5-Aza-CdR;
Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes
Keywords: Acadm; medium-chain acyl-CoA dehydrogenase; AMPKα; AMP-activated protein kinase, α subunit; AST; aspartate aminotransferase; ALT; alanine aminotransferase; BSO; buthionine sulfoximine; CBS; cystathionine-β-synthetase; CPT1a; carnitine palmitoyltransfer
DNA methylation signatures: Biomarkers of drug and alcohol abuse
Keywords: Epigenetics; DNA methylation; Drug of abuse; Alcohol; Gene promoters; Hypermethylation;
NDRG2, suppressed expression associates with poor prognosis in pancreatic cancer, is hypermethylated in the second promoter in human gastrointestinal cancers
Keywords: NDRG2; Hypermethylation; Type II transcript; Gastrointestinal cancers; NDRG2; N-myc downstream regulated gene 2; 5-aza-dC; 5-Aza-2'deoxycytidine; TSA; Trichostatin A; qRT-PCR; quantitative reverse transcription polymerase chain reaction; cDNA; complementa
PAQR3 overexpression suppresses the aggressive phenotype of esophageal squamous cell carcinoma cells via inhibition of ERK signaling
Keywords: Aggressiveness; ERK; Growth; Hypermethylation; Invasion; PAQR3;
Genetic and epigenetic regulation on the transcription of GABRB2: Genotype-dependent hydroxymethylation and methylation alterations in schizophrenia
Keywords: Hypermethylation; RNA expression; SNP; 5hmC/5mC; 5-azacytidine; Valproic acid;
HMGA2, a driver of inflammation, is associated with hypermethylation in acute liver injury
Keywords: HMGA2; the High Mobility Group A protein2; ALI; acute liver injury; KCs; Kupffer cells; LPS; lipopolysaccharide; H&E; hematoxylin eosin staining; IFN-γ; interferon gamma-γ; iNOS; induciblenitricoxide synthase; TNF-α; tumor necrosis factor; Mrc-2; Manno
Counter regulation of ECRG4 gene expression by hypermethylation-dependent inhibition and the Sp1 transcription factor-dependent stimulation of the c2orf40 promoter
Keywords: Sp1 transcription factor; Hypermethylation; Promoter; Jurkat cells; RACE; C2orf40; chromosome 2 open reading frame number 40; ECRG4; Esophageal Cancer Related Gene-4; Sp1; specific protein-1; RACE; Rapid Amplification of cDNA Ends; ChIP; Chromatin immunop
Electrochemical biosensing strategies for DNA methylation analysis
Keywords: DNA methylation; Electrochemical detection; Hypermethylation; Hypomethylation; Global methylation; Regional methylation;
The green tea polyphenol EGCG alleviates maternal diabetes-induced neural tube defects by inhibiting DNA hypermethylation
Keywords: DNA methyltransferases; Epigallocatechin gallate; essential gene; green tea polyphenol; hypermethylation; maternal diabetes; neural tube closure; neural tube defects;
Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2–mutated blastic plasmacytoid dendritic cell neoplasm
Keywords: Blastic plasmacytoid dendritic cell neoplasm; d-2-hydroxyglutarate; IDH mutation; Hypermethylation; Oncometabolite
DNA methylation of channel-related genes in cancers
Keywords: Hypermethylation; Hypomethylation; Ion channel expression; Ion channel gene promoter; Cancer biomarkers
Promoter hypermethylation of membrane type 3 matrix metalloproteinase is associated with cell migration in colorectal adenocarcinoma
Keywords: MT3-MMP; MMP16; colorectal cancer; hypermethylation; migration;
Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2â²-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics
Keywords: Nanoparticles; Drug delivery; TFAP2E; Hypermethylation; Epigenetic drugs;
Inhibition of p16 tumor suppressor gene expression via promoter hypermethylation in canine lymphoid tumor cells
Keywords: Dog; Hypermethylation; Lymphoma; p16; Tumor suppressor gene
E-cadherin gene promoter hypermethylation may contribute to the risk of bladder cancer among Asian populations
Keywords: CDH1, E-cadherin; MSP, methylation specific polymerase chain reaction; RR, risk ratio; CI, confidence interval; NOS, the Newcastle–Ottawa ScaleE-cadherin; Hypermethylation; Bladder cancer; Meta-analysis
Reduction of TIP30 in esophageal squamous cell carcinoma cells involves promoter methylation and microRNA-10b
Keywords: TIP30; ESCC; Hypermethylation; miR-10b;
Reduced expression of Connexin26 and its DNA promoter hypermethylation in the inner ear of mimetic aging rats induced by d-galactose
Keywords: Cx26; Connexin26; AHL; age-related hearing loss; CD; common deletion; ROS; reactive oxygen species; GJs; gap junctions; GJB2; gap junction protein beta-2; Presbycusis; Connexin26; Common deletion; Hypermethylation; Aging;
SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages
Keywords: RAW264.7 mouse macrophage cell line; Suppressors of cytokine signaling1 (SOCS1); Hypermethylation; DNA methyltransferase1 (DNMT1); Pro-inflammatory cytokines; LPS; lipopolysaccharide; TNF-α; tumor necrosis factor-α; IL-6; interleukin 6; SOCS; suppressor
Promoter hypermethylation of DNA repair genes MLH1 and MSH2 in adenocarcinomas and squamous cell carcinomas of the lung
Keywords: Adenocarcinoma; Squamous cell carcinoma; Lung; Hypermethylation; MLH1; MSH2Adenocarcinoma; Carcinoma das células escamosas; Pulmão; Hipermetilação; MLH1; MSH2
Colorectal Carcinomas With CpG Island Methylator Phenotype 1 Frequently Contain Mutations in Chromatin Regulators
Keywords: Colon Cancer; Hypermethylation; Microsatellite Instability; Gene Silencing; CIMP; CpG island methylator phenotype; CRC; colorectal carcinoma; SNP; single-nucleotide polymorphism; TCGA; The Cancer Genome Atlas;
Cisplatin-induced downregulation of SOX1 increases drug resistance by activating autophagy in non-small cell lung cancer cell
Keywords: SOX1; Cisplatin; Hypermethylation; Non-small cell lung cancer;
CHFR aberrant methylation involves a subset of human lung adenocarcinoma associated with poor clinical outcomes
Keywords: Lung; Adenocarcinoma; CHFR; EGFR; EML4-ALK; KRAS; Hypermethylation; Mutation;
Hyper-methylated miR-203 dysregulates ABL1 and contributes to the nickel-induced tumorigenesis
Keywords: NSTCs; Ni3S2-transformed 16HBE cells; Nickel; Tumorigenesis; miR-203; Hypermethylation; ABL1;
Clinical Subtypes and Molecular Characteristics of Serrated Polyposis Syndrome
Keywords: Serrated Polyps; Molecular Markers; Hypermethylation; Hyperplastic Polyps; BMI; body mass index; CIMP; CpG island methylator phenotype; CRC; colorectal cancer; SD; standard deviation; SPS; serrated polyposis syndrome; WHO; World Health Organization;
Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium
Keywords: Cd, cadmium; BCd, blood cadmium; UCd, urinary cadmium; NAG, N-acetyl-β-d-glucosaminidase; B2M, β2-microglobulin; Alb, albumin; Scr, serum creatinine; eGFR, estimated glomerular filtration rateCadmium; Hypermethylation; KLOTHO; Pyrosequencing; RASAL1; Rena
Mechanism of allopurinol induced TPMT inhibition
Keywords: Thiopurine; Hypermethylation; Mechanism; Inhibition; Thiopurine-S-methyltransferase; Allopurinol
The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia
Keywords: Krüppel-like factors; KLF5; Transcription factor; Granulocyte differentiation; Acute myeloid leukemia; Hypermethylation; Tumor suppressor
Epidemiology, Aetiology, and Pathogenesis of Renal Cell Carcinoma
Keywords: Renal cancer; Etiology; VHL gene; Hypermethylation; Folliculin
CHD5, a tumor suppressor that is epigenetically silenced in lung cancer
Keywords: CHD5; Epigenetic silenced; Hypermethylation; Lung cancer; Tumor suppressor;
Helicobacter pylori infection promotes methylation of WWOX gene in human gastric cancer
Keywords: WWOX; Hypermethylation; Gastric cancer; Helicobacter pylori
Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650
Keywords: NDRG2; Hypermethylation; Colorectal cancer; miR-650;
Quantitative evaluation of p16INK4a promoter methylation using pyrosequencing in de novo diffuse large B-cell lymphoma
Keywords: Diffuse large B-cell lymphoma; p16INK4a; Hypermethylation; Pyrosequencing; Methylation-specific PCR;
Hypermethylated DAPK in serum DNA of women with uterine leiomyoma is a biomarker not restricted to cancer
Keywords: OvCa; ovarian cancer; DAPK; death associated protein kinase; IVF; in-vitro fertilization; MSP; methylation specific PCR; MF; methylation frequency; Ovarian cancer; Diagnostic serum marker; Hypermethylation; Leiomyoma; DAPK;
Hypermethylation of MGMT and DAPK gene promoters is associated with tumorigenesis and metastasis in oral squamous cell carcinoma
Keywords: hypermethylation; metastasis; mouth neoplasm; MS-PCR; p16/MGMT/GSTP1/DAPK
Efficient detection of hepatocellular carcinoma by a hybrid blood test of epigenetic and classical protein markers
Keywords: HCV; HCC; Blood testing; Cell-free DNA; Hypermethylation; Quantitative MSP; Hybrid detector
Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir
Keywords: FHIT; Breast cancer; Kashmir; Mutation; Hypermethylation
The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma
Keywords: 5-Aza-dC, 5-aza-2′-deoxycytidine; CHD5, chromodomain helicase DNA-binding protein 5; LSCC, laryngeal squamous cell carcinoma; mRNA, messenger RNA; PCR, polymerase chain reaction; TSA, trichostatin A; TSG, tumor suppressor geneCHD5; Hypermethylation; Laryn
A Comprehensive Analysis of p16 Expression, Gene Status, and Promoter Hypermethylation In Surgically Resected Non-small Cell Lung Carcinomas
Keywords: p16; Expression; Deletion; Hypermethylation; Non-small cell lung cancer
DNA hypermethylation as a chemotherapy target
Keywords: DNA methylation; DNA methyltranferases; Hypermethylation; Cancer; DNMT inhibitors
Methylated cyclin D2 gene circulating in the blood as a prognosis predictor of hepatocellular carcinoma
Keywords: CCND2; HCC; Cell-free DNA; Hypermethylation; Quantitative MSP
DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection
Keywords: Hypermethylation; HBV; HCV; Hepatocellular carcinoma
The DNA methylome of glioblastoma multiforme
Keywords: DNA methylation; Hypermethylation; Hypomethylation; Microarrays; Glioblastoma multiforme
Frequent Epigenetic Inactivation of Deleted in Lung and Esophageal Cancer 1 Gene by Promoter Methylation in Non–Small-Cell Lung Cancer
Keywords: 5-Aza-dC; Biomarker; DLEC1; Hypermethylation
A common mutation of the MYH gene is associated with increased DNA oxidation and age-related diseases
Keywords: 8-OHdG, 8-hydroxy-2′-deoxyguanosine; BER, base excision repair; IL-1, interleukin-1; MYH, human MutY glycosylase homologMYH gene; 8-OHdG; Hypermethylation; Inflammation; Oxidative DNA damage; IL-1; Free radicals
DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type
Keywords: Hypermethylation; Lung cancer; Gender; Histology
p16INK4A inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos
Keywords: Lung cancer; Asbestos; Occupation; Tobacco smoking; P16/CDKN2A; INK4A; Deletion; Hypermethylation