کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899591 | 1084396 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SUMOylation of insulin-like growth factor 1 receptor, promotes proliferation in acute myeloid leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: SUMOylation of insulin-like growth factor 1 receptor, promotes proliferation in acute myeloid leukemia SUMOylation of insulin-like growth factor 1 receptor, promotes proliferation in acute myeloid leukemia](/preview/png/10899591.png)
چکیده انگلیسی
Current valid treatments for acute myeloid leukemia (AML) include chemotherapy and hematopoietic stem cell transplantation, which are defective and limited respectively. The insulin-like growth factor 1 receptor (IGF-1R) is up-regulated in many solid tumors; therefore, it may be a target for tumor therapy. Interestingly, IGF-1R is modified by SUMOylation, a type of reversible post-translational modification. In this study, we found that IGF-1R was increased in both cell lines and clinical samples of AML and was modified by SUMO-1. Furthermore, IGF-1, ligand of IGF-1R, induced the up-regulation of IGF-1R and increased the proliferation of leukemia cell line. After mutation of Lys1025 and Lys1100 in IGF-1R, the evolutionarily conserved lysine residues were identified as the SUMOylation sites of IGF-1R, because the SUMOylation of IGF-1R in these mutants was significantly inhibited. Furthermore, the cell proliferation mediated by IGF-1 was also reduced. After inhibition of UBC9, the activating enzyme of SUMOylation, co-expression of IGF-1R and SUMO-1 was down-regulated, and cell proliferation was also inhibited. However, cell apoptosis was not significantly affected. These results suggest that IGF-1R and its SUMOylation may be a new therapeutic target for strategy of AML.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 357, Issue 1, 1 February 2015, Pages 297-306
Journal: Cancer Letters - Volume 357, Issue 1, 1 February 2015, Pages 297-306
نویسندگان
Jian Zhang, Fang-Fang Huang, Deng-Shu Wu, Wen-Jin Li, Hui-En Zhan, Min-Yuan Peng, Peng Fang, Peng-Fei Cao, Meng-Meng Zhang, Hui Zeng, Fang-Ping Chen,