MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5

- We verified miR-15a/16 and miR-132 was significant down-regulated in invasive pituitary tumor tissues.
- We demonstrated that miR-15a/16 and miR-132 synergistically inhibit Sox5 expression.
- We claimed a model that is three miRNAs deregulation contributed to the tumorigenesis of invasive pituitary tumor.