Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA

► Mdm2 binds to the Slug mRNA and increases its stability regardless of p53 expression. ► Mdm2 increases the Slug protein levels and cellular invasiveness selectively in p53-null cells. ► The stabilization of Slug mRNA is a novel mechanism whereby Mdm2 promotes tumor progression in a p53-independent manner.