Cell cycle arrest and apoptosis induced by O-acetyl-GD2-specific monoclonal antibody 8B6 inhibits tumor growth in vitro and in vivo

► We studied the anti-tumor mechanisms of mAb 8B6 specific to OAcGD2. ► Antibody 8B6 induces tumor cell cycle arrest and tumor cell apoptosis in vitro.. ► Antibody 8B6 triggers the mitochondrial apoptotic pathway with caspase 3 activation. ► Antibody 8B6's apoptotic properties results in tumor growth inhibition in vivo.