A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells

► Our study showed that 7c could induce cancer cells apoptosis but have less cytotoxicity in normal human cell. ► The idea of naphthalimides modification may also provide a novel strategy for naphthalimides design. ► 7c may serve as a lead compound for the potential clinical anticancer drug.