Multi-layer polymeric implants for sustained release of chemopreventives

► Coated polymeric implants reduce initial burst release and accommodate heat labile compounds. ► Coated polymeric implants deliver almost sustained levels of chemopreventives for long duration (months). ► Polymeric implants deliver agents directly systemically and circumvents the oral bioavailability issues. ► Withaferin A via implants elicits antitumor response and reduce the required total dose versus the traditional routes. ► The implant delivery will allow the efficacy assessment of minor plant constituents and synthetic metabolites in vivo.