Keywords: با aaaferin A; GEO; NCBI Gene Expression Omnibus; GES; Gene Expression Signature; TCT; Tocotrienols; LB; Lactobacillus; AMF; Amorfrutin; I3C; Indole-3-carbinol; RSM; Rosemary; CA; Carnosic Acid; WFNA; Withaferin A; SFN; Sulforaphane; RVT; Resveratrol; TRVT; Transresvera
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Keywords: با aaaferin A; AA-PEG; aminoethylanisamide-polyethylene glycol; AD; Alzheimer's disease; BBB; blood-brain barrier; BDNF; brain derived neurotrophic factor; CML; Chronic Myeloid Leukemia; CPPs; cell penetrating peptides; c(RGDyK; cyclo(Arg-Gly-Asp-D-Tyr-Lys) peptide; DSP
Keywords: با aaaferin A; Withania somnifera; Withanolide; Elicitation; Glucose uptake; Withaferin A;
Withaferin A and sulforaphane regulate breast cancer cell cycle progression through epigenetic mechanisms
Keywords: با aaaferin A; Withaferin A; Sulforaphane; Combinatorial therapy; Adjuvant; Breast cancer; Chemotherapy;
Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress
Keywords: با aaaferin A; Withaferin A; Ischemia/reperfusion; Oxidative stress; Antioxidant; Akt;
Astrocyte elevated gene-1 is a novel regulator of astrogliosis and excitatory amino acid transporter-2 via interplaying with nuclear factor-κB signaling in astrocytes from amyotrophic lateral sclerosis mouse model with hSOD1G93A mutation
Keywords: با aaaferin A; ALS; Amyotrophic lateral sclerosis; AEG-1; Astrocyte elevated gene-1; ACM; astrocyte-conditioned medium; CBP; CREB-binding protein; COX-2; Cyclooxygenase-2; DMSO; dimethyl sulfoxide; DL-NBP; DL-3-n-butylphthalide; DMEM; Dulbecco modified Eagle medium; EAA
Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies
Keywords: با aaaferin A; Withaferin A; Quantitative chemoproteomics; Quantitative proteomics; Multiple myeloma; Waldenström macroglobulinemia; Pathway analysis;
Protection against cerebral infarction by Withaferin A involves inhibition of neuronal apoptosis, activation of PI3K/Akt signaling pathway, and reduced intimal hyperplasia via inhibition of VSMC migration and matrix metalloproteinases
Keywords: با aaaferin A; Apoptosis cerebral infarction; Matrix metalloproteinases; PI3K/Akt signaling pathway; Vascular smooth muscle cells; Withaferin A;
Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells
Keywords: با aaaferin A; Macrophage; Withaferin A; Apoptosis; NF-κB pathway;
Structure-based design, synthesis, and biological evaluation of withaferin A-analogues as potent apoptotic inducers
Keywords: با aaaferin A; Withaferin A; Compound library; Cytotoxicity; Apoptosis; Structure-activity relationship;
Withaferin A induced impaired autophagy and unfolded protein response in human breast cancer cell-lines MCF-7 and MDA-MB-231
Keywords: با aaaferin A; AO; Acridine orange; AVOs; Acidic vesicular organelles; CT; Chymotrypsin; LC3; Microtubule associated light chain 3; MDC; Mono-Dansyl-Cadaverine; UPS; Ubiquitin-proteasome system; WA; Withaferin A; WT; Wortmannin; EtBr; Ethidium Bromide; SQSTM1; Sequestos
Bovine milk-derived exosomes for drug delivery
Keywords: با aaaferin A; Milk-derived exosomes; Drug delivery; Tumor-targeting; Chemotherapeutic drugs; Chemopreventive agents; miRNA; microRNA; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; PBS; Phosphate-buffered saline; qRT-PCR; Quantitative reverse transc
Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms
Keywords: با aaaferin A; Akt PKB; protein kinase B; APAP; acetaminophen; ALT; alanine aminotransferase; ARE; antioxidant response element; β-Trcp; beta-transducin repeat containing protein; CDDO-Im; 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; Cul3; cullin-3; DMSO;
Identification and quantitative analysis of cellular proteins affected by treatment with withaferin a using a SILAC-based proteomics approach
Keywords: با aaaferin A; Withaferin A; Withania somnifera; Ashwagandha; SILAC-based proteomics analysis; Microglial cell
Cold stress affects antioxidative response and accumulation of medicinally important withanolides in Withania somnifera (L.) Dunal
Keywords: با aaaferin A; APX; ascorbate peroxidase (EC 1.11.1.11); BSA; bovine serum albumin; CAT; catalase (EC 1.11.1.6); DCPIP; 2,6-dichlorophenolindophenol; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; GR; glutathione reductase (EC 1.6.4.2); GSH; reduced glutath
Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells
Keywords: با aaaferin A; Withaferin A; Oxaliplatin; Pancreatic cancer; Apoptosis; ROS; PI3K/AKT pathway;
Astaxanthin and withaferin A block paracrine cytokine interactions between UVB-exposed human keratinocytes and human melanocytes via the attenuation of endothelin-1 secretion and its downstream intracellular signaling
Keywords: با aaaferin A; WFA; withaferin A; SCF; stem cell factor; EDN; endothelin; MSH; melanocyte stimulating hormone; HEE; human epidermal equivalent; MAPK; mitogen activated protein kinase; MITF; microphthalmia-associated transcription factor; HMs; human melanocytes; TYRP1; t
Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling
Keywords: با aaaferin A; NF-κB; NEMO; IKK; Ubiquitin; Withaferin A; NEMO foci; ABC type diffuse large B-cell lymphoma; Apoptosis;
Bioactive withanolides from Withania obtusifolia
Keywords: با aaaferin A; Withania obtusifolia; Cytotoxicity; Withanolides; Withaferin A; 17β-Hydroxysteroid dehydrogenase; 5α-Reductase;
Axl is a novel target of withaferin A in the induction of apoptosis and the suppression of invasion
Keywords: با aaaferin A; Withaferin A; Axl; Gas6; Migration; Apoptosis
Antiplatelet, anticoagulant, and profibrinolytic activities of withaferin A
Keywords: با aaaferin A; Withaferin A; Fibrinolysis; Anticoagulant; HUVEC
Withaferin A is an inhibitor of endothelial protein C receptor shedding in vitro and in vivo
Keywords: با aaaferin A; Withaferin A; EPCR shedding; PMA; CLP;
Withaferin A modulates the Spindle Assembly Checkpoint by degradation of Mad2–Cdc20 complex in colorectal cancer cell lines
Keywords: با aaaferin A; Withaferin A; Spindle assembly checkpoint; Mad2; Cdc20; Chromosome instability
Withaferin A-stimulated Ca2+ entry, ceramide formation and suicidal death of erythrocytes
Keywords: با aaaferin A; Phosphatidylserine; Withaferin A; Calcium; Cell volume; Eryptosis;
Production of reactive oxygen species by withaferin A causes loss of type collagen expression and COX-2 expression through the PI3K/Akt, p38, and JNK pathways in rabbit articular chondrocytes
Keywords: با aaaferin A; WFA; withaferin A; ROS; reactive oxygen species; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; NAC; N-acetyl-l-cysteine; OA; osteoarthritis; ECM; extracellular matrix; PI3K/Akt; phosphatidylinositol 3-kinase; MAPK; mitogen-activated protein kinase; JNK
Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics after oral administration of Withania somnifera aqueous extract
Keywords: با aaaferin A; Withania somnifera; Withaferin A; Withanolide A; Pharmacokinetic study; HPLC-ESI-MS/MS; Tandem mass spectrometry
Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
Keywords: با aaaferin A; Withaferin A; STAT3; JAK2; Apoptosis
A novel combination of withaferin A and sorafenib shows synergistic efficacy against both papillary and anaplastic thyroid cancers
Keywords: با aaaferin A; Anaplastic thyroid cancer; Papillary thyroid cancer; Sorafenib; Withaferin A; Synergistic effects; Novel therapy
Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A
Keywords: با aaaferin A; Ovarian cancer; Withaferin A; Notch
Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines
Keywords: با aaaferin A; Cisplatin; Withaferin A; Ovarian cancer; Combination treatment; ROS; DNA damage;
Multi-layer polymeric implants for sustained release of chemopreventives
Keywords: با aaaferin A; Polycaprolactone; Curcumin; Withaferin A; Oltipraz; DNA adducts; Lung tumor xenograft; Bioavailability; Drug delivery; Curcuminoids;
Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal models
Keywords: با aaaferin A; WFA; withaferin A; HMGB1; high mobility group box 1 protein; HUVEC; human umbilical vein endothelial cell; CAM; cell adhesion molecule; TNF-α; tumor necrosis factor-α; NF-κB; nuclear factor-κB; EC; endothelial cell; LPS; lipopolysaccharide; VCAM; vasc
Molecular insight in the multifunctional activities of Withaferin A
Keywords: با aaaferin A; Withaferin A; Carcinogenesis; Inflammation; Angiogenesis; Therapy;
Blocking the chaperone kinome pathway: Mechanistic insights into a novel dual inhibition approach for supra-additive suppression of malignant tumors
Keywords: با aaaferin A; Chaperone; Hsp90; 17-DMAG; Withania somnifera; Withaferin A;
Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells
Keywords: با aaaferin A; Withaferin A; Microglia; COX-2; STAT
Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells
Keywords: با aaaferin A; Withaferin A; Endoplasmic reticulum stress; Apoptosis; CHOP; Unfolded protein response;
Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition
Keywords: با aaaferin A; Withaferin A; Radiation; Apoptosis; Reactive oxygen species; Bcl-2;
Combination of withaferin A and X-ray irradiation enhances apoptosis in U937 cells
Keywords: با aaaferin A; Withaferin A; Radiation; Apoptosis; Reactive oxygen species; Bcl-2;
Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential
Keywords: با aaaferin A; Withaferin A; Michael addition; 3+2 Cycloaddition; α,β-Unsaturated group; Cytotoxicity;
Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line
Keywords: با aaaferin A; Withania somnifera; Withanolides; Withaferin A; Cytotoxicity; Lung cancer cell line (NCI-H460);
Withaferin A targets heat shock protein 90 in pancreatic cancer cells
Keywords: با aaaferin A; Withaferin A; Pancreatic cancer; Hsp90; Reactive cysteine; Client protein; Cdc37
Withaferin A inhibits tumor necrosis factor-α-induced expression of cell adhesion molecules by inactivation of Akt and NF-κB in human pulmonary epithelial cells
Keywords: با aaaferin A; Withaferin A; Inflammatory disease; Intercellular adhesion molecule-1; Vascular cell adhesion molecule-1; Nuclear factor-κB; A549 cells
Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP
Keywords: با aaaferin A; Withaferin A; ROS; TRAIL; DR5; c-FLIP; CHOP; NF-κB; Free radicals
Withaferin A inhibits iNOS expression and nitric oxide production by Akt inactivation and down-regulating LPS-induced activity of NF-κB in RAW 264.7 cells
Keywords: با aaaferin A; Withaferin A; Nitric oxide; iNOS; NF-κB; Akt