کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10900076 1084475 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway
چکیده انگلیسی
The drs gene is an apoptosis-inducing tumor suppressor. By using drs-knockout (KO) mouse embryonic fibroblasts (MEFs), we showed that drs is involved in the host defense against viral infection. In drs-KO MEFs infected with vesicular stomatitis virus, the viral replication and protein synthesis were markedly enhanced without the upregulation of the cellular protein synthesis. Phosphorylation of S6K, S6, 4EBP1 and TSC2 proteins was closely correlated with the enhanced viral replication in drs-KO MEFs. Drs protein could associate with stress-inducible GADD34 to form a complex with TSC1/2, which suppresses mTOR activity. These findings indicate that Drs suppresses viral replication via mTOR-dependent pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 314, Issue 1, 1 January 2012, Pages 82-91
نویسندگان
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