Keywords: ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; AMPK; AMP-activated protein kinase; AD; Alzheimer's disease; ARE; antioxidant response element; ATF6; activating transcription factor 6; BiP; binding immunoglobulin protein; BRAC1; Breast cancer 1
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Keywords: PAH; pulmonary artery hypertension; PBS; phosphate buffer; qRT-PCR; quantitative real time; ARDS; acute respiratory distress syndrome; ARE; anti-oxidant responsive element; Atg4; autophagy related 4; ATF6; activating transcription factor 6; Chop; C/EBP [C
Keywords: ER stress; KSHV; IRE1α; PERK; Primary effusion lymphoma; Unfolded protein response; ATF6; activating transcription factor-6; CHOP; CCAAT/enhancer-binding protein-homologous protein; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage gene-34;
Keywords: αKG; alpha ketoglutarate; BCAA/LEU; branched chain amino acids enriched with l-leucine; CHOP; C/EBP homology protein; eIF2α; eukaryotic initiation factor 2 alpha; GADD34; growth arrest and DNA damage inducible protein 34; GCN2; general control non-depre
Keywords: ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bcl-2; B-cell lymphoma 2; BiP; binding immunoglobulin protein; bZIP; basic leucine zipper; CDK; cyclin-dependent kinase; CDKI; CD
Protection by different classes of dietary polyphenols against palmitic acid-induced steatosis, nitro-oxidative stress and endoplasmic reticulum stress in HepG2 hepatocytes
Keywords: Non-alcoholic fatty liver disease; Functional food polyphenols; Endoplasmic reticulum stress; Oxidative stress; Mitochondrial dysfunction; AMPK; AMP-activated protein kinase; ATP5G1; ATP synthase, mitochondrial Fo complex, subunit C1 (subunit 9); CCCP; ca
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2
Keywords: ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; eIF2α; eukaryotic initiation factor 2 alpha; eIF2α-P; phosphorylated eukaryotic initiation factor 2; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage protein 34; GCN
Targeting chaperones, heat shock factor-1, and unfolded protein response: Promising therapeutic approaches for neurodegenerative disorders
Keywords: 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin (tanespimycin); 17-DMAG; 17- dimethylaminoethylamino-17-demethoxygeldanamycin (alvespimycin); AAV; adeno-associated virus; Aβ; amyloid-β; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP;
VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal
Keywords: Ovarian cancer; DBeQ; ML240; Salubrinal; ER stress; Unfolded protein response; CB-5083; Synergy; AAA-ATPase; ATPase associated with diverse cellular activities; BRCA1/2; breast cancer 1/2; PARP1; poly ADP-ribose polymerase-1; DBeQ; N2,N4-dibenzylquinazoli
Increased GADD34 in oligodendrocytes in Alzheimer’s disease
Keywords: Alzheimer’s disease; Oligodendrocytes; GADD34; ER stress
Quercetin reduces eIF2α phosphorylation by GADD34 induction
Keywords: GADD34; ATF4; Quercetin; Amyloid-β; Alzheimer's disease;
Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game
Keywords: ADAMTS; A Disintegrin And Metalloproteinase with Thrombospondin Motifs; BMP; bone morphogenic protein; CaMK; Ca2Â +/calmodulin-dependent protein kinase; CaN; calcineurin; CNA, CNB; calcineurin catalytic (A) and regulatory (B) subunits; COX; cyclooxygenase
Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6K
Keywords: PBMC; peripheral blood mononuclear cell; FCS; fetal calf serum; FITC; fluorescein isothiocyanate; LPS; lipopolysaccharide; HBSS; Hank's balanced salt solution; PI3K; mammalian target of rapamycin; mTOR; phosphoinositide 3-kinase; mTORC1; multi-component m
Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress
Keywords: a.a.; amino acid; ATF; activating transcription factor; Bcl-2; B-cell lymphoma 2; Bcl-Xl; B-cell lymphoma-extra large; BH3; Bcl-2 homology 3; BI-1; Bax inhibitor-1; BiP; immunoglobulin heavy chain-binding protein; CHOP; C/EBP-homologous protein; CSQ; cals
ER stress-induced cell death mechanisms
Keywords: AGE; advanced glycated end-products; ALS; amyotropic lateral sclerosis; AMD; age-related macular degeneration; ARE; antioxidant response elements; ASK1; apoptotic-signaling kinase-1; ATF4; activating transcription factor 4; ATF6; activating transcription
Redox signaling loops in the unfolded protein response
Keywords: AGR2; anterior gradient 2; ARE; antioxidant responsive element; ATF4; activating transcription factor-4; ATF6; activating transcription factor-6; ASK1; apoptosis signal-regulating kinase-1; BI-1; BAX inhibitor-1; BiP; immunoglobulin heavy chain-binding pr
Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway
Keywords: drs; Host defense; mTOR pathway; GADD34; Knockout mouse;
GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway
Keywords: Autophagy; GADD34; TSC; mTOR; Cell death; HDACC, Acetyl-CoA carboxylase; AMPK, AMP-activated protein kinase; ATF4, activating transcription factor 4; Bcl-2, B-cell CLL/lymphoma 2; CHOP, CCAAT/enhancer binding protein (C/EBP) homologous protein also called
Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation
Keywords: Starvation; Gadd34; Autophagy; mTOR;
Research ArticleGlycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis
Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FFA; free fatty acids; ER; endoplasmic reticulum; PERK; protein kinase RNA-like ER kinase; IRE-1α; inositol-requiring protein-1α; CHOP; C/EBP-homologous protein; GADD34; growth
Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion
Keywords: DDIT3; Ischemic Damage; Intestinal Microbiota; Inflammatory Bowel Disease; ATF6; activating transcription factor 6; BiP; binding protein; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage-inducible protein 3
Overexpression of GADD34 Enhances Production of Recombinant Human Antithrombin III in Chinese Hamster Ovary Cells
Keywords: Chinese hamster ovary cells; GADD34; antithrombin III
Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
Keywords: ATF4, activating transcription factor 4; BiP, immunoglobulin heavy chain binding protein; CHOP, C/EBP homologous protein; EDEM, ER degradation-enhancing α-mannosidase-like protein; eIF-2α, eukaryotic initiation factor-2α; ER, endoplasmic reticulum; GADD34
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Keywords: 1O2; singlet oxygen; ÎÏm; mitochondrial transmembrane potential; [Ca2+]cyt; cytosolic Ca2+-concentration; AlPc; aluminum phthalocyanine; ALA; 5-aminolevulinic acid; AIF; apoptosis inducing factor; ANT; adenine nucleotide translocator; Apaf-1; apoptosis
Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia
Keywords: GADD34; Myocardial ischaemia; Protein synthesis; Cell death; Cerebral ischaemia;
Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus
Keywords: V. parahaemolyticus; TDH; TTSS; Apoptosis; Microarray; Egr; ATF3; Gadd34;