کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10900373 1084638 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells
چکیده انگلیسی
Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines xanthopterin and isoxanthopterin was studied using the MTS assay for measurement of cell viability. The pteridines were tested at concentrations ranging from 7.8 to 500 μM singly and in 11 isoxanthopterin:xanthopterin ratios. IC50s of xanthopterin and isoxanthopterin were 109±13 μM (mean±SEM of y estimate) and 103±9 μM, respectively. The IC50 values for pteridine mixtures were similar although 3:1 and 4:1 isoxanthopterin:xanthopterin ratios seemed slightly more cytotoxic than other mixtures. However, ANOVA revealed no statistical differences in the cytotoxicity of mixtures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 222, Issue 1, 10 May 2005, Pages 119-124
نویسندگان
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