Estradiol-induced ezrin overexpression in ovarian cancer: a new signaling domain for estrogen

We have for the first time exposed estrogen's role in the epithelial ovarian cancer (OVCA) metastatic cascade and discovered that it is related to the induction of ezrin over-expression. 17β Estradiol (E2) was administered to SKOV3 (ERα>β) and DOV13 (ERα