کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10902507 | 1085058 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population](/preview/png/10902507.png)
چکیده انگلیسی
GSTA1 has been reported to be most efficient in detoxifying N-acetoxy PhIP. In this study, 341 Japanese urothelial cancer patients and 457 healthy controls were compared for frequencies of GSTA1 genotype. We present the first evidence of an association between GSTA1*B (-567G, -69T, -52A) and urothelial cancer among never smokers. The frequency of GSTA1 *A/*B or *B/*B genotype was 24.3% in urothelial cancer cases, compared with 21.2% in the control groups (OR=1.22; 95%CI 0.87-1.72) after adjustment for age, gender and smoking status. But among never smokers, the GSTA1 *A/*B or *B/*B genotype was significantly higher in urothelial cancer cases (31.2%) compared with the controls (19.9%) (OR=1.73; 95%CI 1.01-2.97). This study suggests that exposure to food-derived PhIP could be one of the risk factors in the incidence of urothelial cancer in never smokers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 221, Issue 1, 18 April 2005, Pages 55-59
Journal: Cancer Letters - Volume 221, Issue 1, 18 April 2005, Pages 55-59
نویسندگان
Yasuhiro Komiya, Hiromasa Tsukino, Hiroyuki Nakao, Yoshiki Kuroda, Hirohisa Imai, Takahiko Katoh,