Ca2+ signaling regulates ecmB expression, cell differentiation and slug regeneration in Dictyostelium

► Ca+2 and calmodulin (CaM) regulate Dictyostelium slug regeneration. ► Ca+2 and CaM regulate ecmB expression and pstAB/pstB cell differentiation. ► Ca+2 and CaM regulate shape regeneration and cell/slug motility.