کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10903390 | 1085463 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Xenopus connexins: how frogs bridge the gap
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Animal species use specialized cell-to-cell channels, called gap junctions, to allow for a direct exchange of ions and small metabolites between their cells' cytoplasm. In invertebrates, gap junctions are formed by innexins, while vertebrates use connexin (Cx) proteins as gap-junction-building blocks. Recently, innexin homologs have been found in vertebrates and named pannexins. From progress in the different genome projects, it has become evident that every class of vertebrates uses their own unique set of Cxs to build their gap junctions. Here, we review all known Xenopus Cxs with respect to their expression, regulation, and function. We compare Xenopus Cxs with those of zebrafish and mouse, and provide evidence for the existence of several additional, non-identified, amphibian Cxs. Finally, we identify two new Xenopus pannexins by screening EST libraries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Differentiation - Volume 73, Issue 7, September 2005, Pages 330-340
Journal: Differentiation - Volume 73, Issue 7, September 2005, Pages 330-340
نویسندگان
Teun P. de Boer, Marcel A.G. van der Heyden,