کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10909241 1087843 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?
چکیده انگلیسی
Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 36, Issue 5, May 2012, Pages 594-597
نویسندگان
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