کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10909531 | 1087910 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of various MLL gene aberrations that lead to MLL gene mutation in patients with acute lymphoblastic leukemia (ALL) and infants with acute leukemia
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کلمات کلیدی
MLLWCPAMLT-ALL - بلند قدSouthern blotting - بلوط جنوبfluorescence in situ hybridization - فلورسانس در هیبریداسیون در محلacute myeloid leukemia - لوسمی حاد میلوئیدی یا به اختصار AMLT-cell acute lymphoblastic leukemia - لوسمی لنفوبلاستی حاد T-cellAcute lymphoblastic leukemia - لوسمی لنفوبلاستیک حادFish - ماهیwhole chromosome painting - نقاشی کامل کروموزومALL - همه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of various MLL gene aberrations that lead to MLL gene mutation in patients with acute lymphoblastic leukemia (ALL) and infants with acute leukemia Identification of various MLL gene aberrations that lead to MLL gene mutation in patients with acute lymphoblastic leukemia (ALL) and infants with acute leukemia](/preview/png/10909531.png)
چکیده انگلیسی
Studies were done to investigate MLL gene aberrations using Conventional Cytogenetics, Southern blotting as well as FISH using a panel of probes on 218 cases which included 206 cases of pediatric/young adult ALL and 12 cases of infantile acute leukemias from Tata Memorial Hospital, India. The incidence of MLL gene rearrangements in acute lymphoblastic leukemia (ALL) was 9.4% which included infants as well as pediatric/young adults. In infantile group which included ALL as well as AML cases, MLL gene rearrangement was very common (75% frequency). Application of metaphase-FISH helped unravel MLL rearrangements not only as a result of translocations but also inversions, insertions, partial deletion, duplications, partial duplicationâself-fusion. Besides age, MLL gene rearrangements showed significant association with hyperleukocytosis, peripheral blood blast percentage and early Pre-B phenotype. Clinical outcome of patients with MLL gene rearrangements revealed unfavorable prognosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 29, Issue 5, May 2005, Pages 517-526
Journal: Leukemia Research - Volume 29, Issue 5, May 2005, Pages 517-526
نویسندگان
Anurita Pais, Pratibha Amare Kadam, Gauri Raje, Manisha Sawant, Sharayu Kabre, Hemani Jain, Suresh Advani, Shripad Banavali,