کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10911365 | 1088292 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunosuppression and lung cancer of donor origin after bilateral lung transplantation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunosuppression and lung cancer of donor origin after bilateral lung transplantation Immunosuppression and lung cancer of donor origin after bilateral lung transplantation](/preview/png/10911365.png)
چکیده انگلیسی
Analysis of databases from transplant recipients revealed a 3-5 fold higher risk to develop de novo malignancies under continued immunosuppression. The underlying mechanisms are poorly understood. Here we describe a patient who received a bilateral lung transplantation for end-stage 'Usual Interstitial Pneumonia' (UIP) resulting in idiopathic lung fibrosis. The recipient presented with a non-small cell lung carcinoma (NSCLC) in the donor lung 7 months later. Molecular and immunological typing of the tumor revealed a cancer of donor origin with a prominent intratumoral immune cell infiltrate without detectable effector function. This is a unique case of de novo outgrowth of a NSCLC of donor origin under continued immunosuppression, supporting the concept of tumor immunosurveillance in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Lung Cancer - Volume 76, Issue 1, April 2012, Pages 118-122
Journal: Lung Cancer - Volume 76, Issue 1, April 2012, Pages 118-122
نویسندگان
Lotta von Boehmer, Alice Draenert, Wolfgang Jungraithmayr, Ilhan Inci, Schäfer Niklaus, Annette Boehler, Markus Hofer, Rolf Stahel, Alex Soltermann, Maries van den Broek, Walter Weder, Alexander Knuth,