کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10913892 | 1088644 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway
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کلمات کلیدی
OECOMPPECAM-1olfactory epithelium - اپیتلیوم بویاییOSN - سازمان ملل متحدolfactory ensheathing cell - سلول تخمگذار بویاییOlfactory Ensheathing Cells - سلول های Ensheating عصارهperipheral nervous system - سیستم عصبی پیرامونیolfactory sensory neuron - عصب حساس بویاییVasculature - مجاورolfactory marker protein - پروتئین مارکر بویایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway](/preview/png/10913892.png)
چکیده انگلیسی
The adult olfactory epithelium has maintained the ability to reconstitute its olfactory sensory neurons (OSNs) from a basal progenitor cell compartment. This allows for life-long turnover and replacement of receptor components as well as repair of the primary olfactory pathway in response to injury and environmental insults. The present study investigated whether fibulin-3, a glycoprotein in the extracellular matrix and binding partner of tissue inhibitor of metalloproteinases-3 (TIMP-3), plays a role in ongoing plasticity and regenerative events in the adult primary olfactory pathway. In wild-type control mice, fibulin-3 protein was detected on IB4+CD31+ blood vessels, nerve fascicles and the basement membrane underneath the olfactory epithelium. After target ablation (olfactory bulbectomy), fibulin-3 was also abundantly present in the central nervous system (CNS) scar tissue that occupied the bulbar cavity. Using two different lesion models, i.e. intranasal Triton X-100 lesion and olfactory bulbectomy, we show that fibulin-3 deficient (Efemp1â/â) mice have impaired recovery of the olfactory epithelium after injury. Ten days post-injury, Efemp1â/â mice showed altered basal stem/progenitor cell proliferation and increased overall numbers of mature (olfactory marker protein (OMP) -positive) versus immature OSNs. However, compromised regenerative capacity of the primary olfactory pathway in Efemp1â/â mice was evidenced by reduced numbers of mature OSNs at the later time point of 42Â days post-injury. In addition to these neural differences there were consistent changes in blood vessel structure in the olfactory lamina propria of Efemp1â/â mice. Overall, these data suggest a role for fibulin-3 in tissue maintenance and regeneration in the adult olfactory pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Matrix Biology - Volume 28, Issue 7, September 2009, Pages 406-415
Journal: Matrix Biology - Volume 28, Issue 7, September 2009, Pages 406-415
نویسندگان
Jana Vukovic, Lihua Y. Marmorstein, Precious J. McLaughlin, Takako Sasaki, Giles W. Plant, Alan R. Harvey, Marc J. Ruitenberg,