کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10914847 | 1088821 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression patterns of bone morphogenetic protein antagonists in colorectal cancer desmoplastic invasion fronts
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کلمات کلیدی
lamb1TGF-βh-caldesmonα-SMAβ-catGrem1FollistatinHtrA3ROCTBSMSIVEGFR2FSTNTBAUC - AUCα-smooth muscle actin - اکتین عضله آلفا صافImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیβ-catenin - بتا-کاتنینTIL - بهMicrosatellite instability - بی ثباتی ریزماهواره ایtransforming growth factor-β - تبدیل فاکتور رشد βEMT - تکنسین فوریتهای پزشکیTumor budding - جوانه زدن تومورColorectal cancer - سرطان روده بزرگCancer-associated fibroblasts - فیبروبلاست های مرتبط با سرطانtumor-infiltrating lymphocyte - لنفوسیت نفوذی تومورarea under the curve - منطقه تحت منحنیepithelial-to-mesenchymal transition - گذار اپیتلیال به مزانشیمالGremlin-1 - گرمیلین 1Vascular endothelial growth factor receptor-2 - گیرنده 2 فاکتور رشد اندوتلیال عروقیreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Bone morphogenetic proteins (BMPs) are a group of growth factors with dual functions in cancer development and progression. Recently, certain tumor-promoting roles have been identified for selected antagonists/inhibitors (BMPIs) of this developmental pathway. A recent focus on the implication of BMP in colorectal cancer progression has emerged, mainly due to the presence of inactivating mutations in several members of the canonical signaling cascade. However, the detailed expression profiles of BMPIs remain largely unknown. Based on our previous work, whereby three specific BMPIs, gremlin-1 (GREM1), high-temperature requirement A3 (HTRA3) and follistatin (FST) were collectively overexpressed in desmoplastic cocultures of colorectal cancer (CRC), here, we undertook an immunohistochemical approach to describe the patterns of their expression in CRC patients. Two major characteristics described the BMPI expression signature: First, the synchronous and coordinated stromal and epithelial overexpression of individual BMPIs in desmoplastic lesions, which demonstrated that all three of them contribute to increasing levels of BMP antagonism in such areas. Second, the presence of microenvironmental polarity in the BMPI pattern of expression, which was indicated through the preferential expression of HTRA3 in the stromal, and the parallel FST/GREM1 expression in the epithelial component of the investigated sections. In addition, expression of HTRA3 in the epithelial compartment of the tumors demonstrated a significant predictive power to discriminate between tumor-budding-bearing and tumor-budding-free desmoplastic microenvironments. Together, these findings contribute to the understanding of signaling dynamics of BMP antagonism in the colorectal cancer desmoplastic invasion front.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 8, Issue 7, October 2014, Pages 1240-1252
Journal: Molecular Oncology - Volume 8, Issue 7, October 2014, Pages 1240-1252
نویسندگان
George S. Karagiannis, Ann Treacy, David Messenger, Andrea Grin, Richard Kirsch, Robert H. Riddell, Eleftherios P. Diamandis,