کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10915675 | 1090101 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diffusion-Weighted Magnetic Resonance Imaging Allows Noninvasive In Vivo Monitoring of the Effects of Combretastatin A-4 Phosphate after Repeated Administration
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کلمات کلیدی
GRAPPAGeneRalized Autocalibrating Partially Parallel AcquisitionVascular targeting agentDW-MRIcombretastatin A-4 phosphateDCE-MRIADCVTAROIstandard deviation - انحراف معیارDynamic contrast-enhanced magnetic resonance imaging - تصویربرداری رزونانس مغناطیسی با کنتراست پویاPositron emission tomography - توموگرافی گسیل پوزیترونAnticancer therapy - درمان ضد سرطانapparent diffusion coefficient - ضریب انتشار آشکارregion of interest - منطقه مورد نظرNecrosis - نکروز یا بافتمردگیVascular targeting - هدف قرار دادن عروقPET - پت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The noninvasive assessment of anticancer treatment efficacy is very important for the improvement of therapeutic window. The purpose of the present study was to evaluate the antitumoral effects of the vascular targeting agent, combretastatin A-4 phosphate (CA-4-P), at selected time points after repeated intraperitoneal drug administrations (25 mg/kg), using diffusion-weighted magnetic resonance imaging (DWMRI). The experiments were performed during an overall follow-up period of 3 weeks on WAG/Rij rats with subcutaneously growing rhabdomyosarcomas. Each animal served as its own baseline. The DW-MRI studies were quantified by calculating the apparent diffusion coefficient (ADC) for different low, high b-values to separate the effects on tumor vasculature, cellular integrity. The changes in ADC as well as the extent of necrosis development (proportional to the tumor volume), measured on the MR images, were of comparable magnitude after each treatment. All ADC values showed a significant decrease at 6 hours, followed by a significant increase at 2 days for various CA-4-P administrations. DW-MRI allowed us to monitor both reduction in perfusion, changes in the extent of tumor necrosis after CA-4-P injection. Repeated CA-4-P administration retains efficacy in rat rhabdomyosarcomas, with similar findings after each drug administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 7, Issue 8, August 2005, Pages 779-787
Journal: Neoplasia - Volume 7, Issue 8, August 2005, Pages 779-787
نویسندگان
Harriet C. Thoeny, Frederik De Keyzer, Feng Chen, Vincent Vandecaveye, Erik K. Verbeken, Bisan Ahmed, Xihe Sun, Yicheng Ni, Hilde Bosmans, Robert Hermans, Allan van Oosterom, Guy Marchal, Willy Landuyt,